percent
tablet
Zenith Pharmaceuticals Ltd.Generic:
Promethazine HydrochlorideWeight:
25 mgbest Price:
? 0.42Generic
Promethazine Hydrochloride
Indications
Potent long-acting antihistamine with additional anti-emetic and sedative/calming effects. Indicated in symptomatic treatment of allergic conditions of the respiratory tract and skin. Sensitization reactions to drug or foreign proteins, anaphylactic reactions. For sedation, allergic rhinitis, urticaria and insomnia. ... Read more Potent long-acting antihistamine with additional anti-emetic and sedative/calming effects. Indicated in symptomatic treatment of allergic conditions of the respiratory tract and skin. Sensitization reactions to drug or foreign proteins, anaphylactic reactions. For sedation, allergic rhinitis, urticaria and insomnia. As an adjunct in pre-operative sedation in surgery and obstetrics. As a paediatric sedative
Pharmacology
Promethazine is a phenothiazine derivative which blocks postsynaptic mesolimbic dopaminergic receptors in the brain. It exhibits strong ?-adrenergic blocking effect and depresses the release of hypothalamic and hypophyseal hormones. It competes with histamine for the H1-receptor; muscarinic blocking effect may be responsible for antiemetic activity. It also reduces stimuli to the brainstem reticular system. Promethazine is well absorbed from the gastrointestinal tract. Clinical effects are apparent within 20 minutes after oral administration and generally last four to six hours, although they may persist as long as 12 hours. Promethazine is metabolized by the liver to a variety of compounds; the sulfoxides of promethazine and N-demethylpromethazine are the predominant metabolites appearing in the urine.
Dosage Administration
Adults: Initial dose one 25 mg tablet at night; may be increased to two or three 25 mg tablets at night if necessary. In allergic conditions more frequently administration, twice or three times daily, may be necessary, starting with one or two 10 mg tablets and increasing as required. Elderly: No specific dosage recommendations. Children: They may be treated more conveniently by the elixir containing 5 mg/5 ml. As an antihistamine in allergy: Children of 2-5 years: 5-15 mg Children of 5-10 years: 10-25 mg In the case where two doses in 24 hours are required, the lower dose stated should be given. As a sedative: Children of 2-5 years: 15-20 mg Children of 5-10 years: 20-25 mg Given as a single night-time dose
Contraindications
Promethazine Hydrochloride may enhance the action of any anticholinergic agent, tricyclic antidepressant, sedative or hypnotic, Alcohol should be avoided during drug treatment. Phenergan may interfere with immunologic urine pregnancy tests to produce false-positive or false-negative results. Phenergan should be discontinued at least 72 hours before the start of skin tests using allergen extracts as it may inhibit the cutaneous histamine response thus producing false-negative results.
Side Effects
Symptoms of severe over dosage are variable. They are characterised in children by various combinations of excitation, ataxia, incoordination, athetosis and hallucinations, while adults may become drowsy and lapse into coma. Convulsions may occur in both adults and children; coma or excitement may precede their occurrence. Tachycardia may develop. Cardiorespiratory depression is uncommon. If the patient is seen soon enough after ingestion, it should be possible to induce vomiting with ipecacuanha despite the antiemetic efect of promethazine; alternatively, gastric lavage may be used. Treatment is otherwise supportive with attention to maintenance of adequate respiratory and circulatory status. Convulsions should be treated with diazepam or other suitable anticonvulsant.
Pregnancy And Lactation
Anti-emetic drugs, Miscellaneous sedatives & hypnotics, Sedating Anti-histamine
Therapeutic
Symptoms of severe over dosage are variable. They are characterised in children by various combinations of excitation, ataxia, incoordination, athetosis and hallucinations, while adults may become drowsy and lapse into coma. Convulsions may occur in both adults and children; coma or excitement may precede their occurrence. Tachycardia may develop. Cardiorespiratory depression is uncommon. If the patient is seen soon enough after ingestion, it should be possible to induce vomiting with ipecacuanha despite the antiemetic efect of promethazine; alternatively, gastric lavage may be used. Treatment is otherwise supportive with attention to maintenance of adequate respiratory and circulatory status. Convulsions should be treated with diazepam or other suitable anticonvulsant.
Storage Conditions
Anti-emetic drugs, Miscellaneous sedatives & hypnotics, Sedating Anti-histamine
Over The Counter Products
