Generic
Perindopril Arginine
Contraindications
Rare and mild: usually at the start of treatment cough, fatigue, asthenia, headache, disturbances of mood and/or sleep have been reported. Less often: Taste impairment, epigastric discomfort, nausea, abdominal pain and rash. Reversible increase in blood urea and creatinine may be observed. Proteinuria has occurred in some patients. Rarely: Angioneurotic edema and decrease in hemoglobin, red cells and platelets have been reported.
Side Effects
Perindopril should not be used during pregnancy & lactation.
Pregnancy And Lactation
In the following cases, Perindopril should be used with caution: Renovascular hypertension Surgery/Anesthesia Renal failure: The dose should be cautiously adjusted in accordance with the creatinine clearance Symptomatic hypotension is rarely seen, but is more likely in volume-depleted patients, those receiving diuretics, or with the first two doses In diuretic-treated patients: stop the diuretic 3 days before starting Perindopril. A diuretic may later be given in combination if necessary; potassium-sparing diuretics are not recommended Combination with neuroleptics or imipramine-type drugs may increase the hypotensive effect. Serum lithium concentrations may rise during lithium therapy
Therapeutic
Perindopril should not be used during pregnancy & lactation.
Storage Conditions
In the following cases, Perindopril should be used with caution: Renovascular hypertension Surgery/Anesthesia Renal failure: The dose should be cautiously adjusted in accordance with the creatinine clearance Symptomatic hypotension is rarely seen, but is more likely in volume-depleted patients, those receiving diuretics, or with the first two doses In diuretic-treated patients: stop the diuretic 3 days before starting Perindopril. A diuretic may later be given in combination if necessary; potassium-sparing diuretics are not recommended Combination with neuroleptics or imipramine-type drugs may increase the hypotensive effect. Serum lithium concentrations may rise during lithium therapy
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