Generic
Folic Acid
Pharmacology
Folic acid, as it is biochemically inactive, is converted to tetrahydrofolic acid and methyltetrahydrofolate by dihydrofolate reductase (DHFR). These folic acid congeners are transported across cells by receptor-mediated endocytosis where they are needed to maintain normal erythropoiesis, synthesize purine and thymidylate nucleic acids, interconvert amino acids, methylate tRNA, and generate and use formate. Using vitamin B12 as a cofactor, folic acid can normalize high homocysteine levels by remethylation of homocysteine to methionine via methionine synthetase.
Dosage Administration
Adults- Initially: 5 mg daily for 4 months. maintenance: 5 mg every 1-7 days depending on the underlying disease. Children- Up to 1 year: 500 mcg/kg daily. Over 1 year: Same as adult dose.
Contraindications
Folic acid is contraindicated in patients who have shown previous intolerance to the drug.
Side Effects
Folic acid is generally well tolerated. Gastro-intestinal disturbances may occur. Hypersensitivity reactions have been reported rarely.
Pregnancy And Lactation
No special precautions are known.
Therapeutic
Store below 30�C in a dry place, away from light. Keep out of the reach of children.
Over The Counter Products
