Reptylin
Tablet
Albion Laboratories LimitedGeneric:
Amitriptyline HydrochlorideWeight:
10 mgbest Price:
? 0.85Generic
Amitriptyline Hydrochloride
Indications
Amitriptyline Hydrochloride is indicated in- Depressive Illness: particularly where sedation is required. Nocturnal Enuresis in children. Prophylaxis of Migraine. Tension Headache. Chronic Pain.
Pharmacology
Amitriptyline is a tricyclic antidepressant. It has marked anticholinergic and sedative properties. It prevents the reuptake of noradrenaline and serotonin at the nerve ending. Amitriptyline hydrochloride is rapidly absorbed from the Gl tract. Peak plasma concentrations occur within 2-12 hours. Amitriptyline is excreted in the urine, mainly in the form of its metabolites.
Contraindications
Anticholinergic: Excessive perspiration, dry mouth, blurred vision, hyperpyrexia, urinary retention and urinary tract dilatation. Cardiovascular reactions: Hypotension, syncope, postural hypotension, hypertension, tachycardia, palpitations, myocardial infarction, etc. CNS and Neuromuscular: Confusional states, disturbed concentration, disorientation, delusions, etc. Allergic: Skin rash, urticaria, photosensitization, etc. Haematological: Bone-marrow depression. Gastrointestinal: Nausea, epigastric distress, vomiting, anorexia, stomatitis, unpleasant taste, weight loss, diarrhoea, constipation, etc. Endocrine: Testicular swelling, gynaecomastia, breast enlargement, galactorrhoea, etc.
Side Effects
Pregnancy Category C. Amitriptyline has been shown to cross the placenta. Amitriptyline should be used during pregnancy only if the potential benefit to the mother justifies the potential risk to the fetus. Amitriptyline is excreted into breast milk. Because of the potential for serious adverse reactions in nursing infants from Amitriptyline, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Pregnancy And Lactation
It should be used with caution in patients with a history of epilepsy, glaucoma, urinary retention, cardiac disease, diabetes, pregnancy, hepatic impairment, thyroid disease, increased intra-ocular pressure and psychoses (may aggravate mania).
Therapeutic
Tricyclic Anti-depressant
Storage Conditions
Tricyclic Anti-depressant
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