Generic
Pivmecillinam
Dosage Administration
Adults: The usual dose: 1-2 tablets 3 times daily according to severity of the infection. In acute uncomplicated cystitis: initially 400 mg then 200 mg every 8 hours for 3 days. In chronic or recurrent bacteriurea: 400 mg 6-8 hours. For the treatment of salmonellosis (including enteric fever): 1.2-2.4 gm daily for 14 days. To eliminate salmonella carriage, therapy may be prolonged for 2-4 weeks. In complicated urinary tract infection the usual treatment time is 1-2 weeks. For prophylactic treatment of recurrent urinary tract infections: 1 tablet every evening is recommended. Children: Weighing less than 20 kg should be given 20-60 mg/kg divided into 3-4 daily doses. Those weighing more than 20 kg should receive normal adult dose. In shigellosis: 20 mg/kg 4 times a day for 5 days. For UTI: 20-40 mg/kg/day in 3-4 divided doses For salmonellosis: 30-60 mg/kg/day in 3-4 divided doses
Contraindications
Mecillinam concentrations approximately 1/3 of the serum levels have been found in the umbilical cord, and low but detectable amounts in the amniotic fluid. So, use of pivmecillinam in pregnancy should be avoided. Mecillinam is not excreted into the milk of lactating mother
Side Effects
As with other antibiotics, which are excreted mainly by the kidneys, raised blood levels of mecillinam may occur if repeated doses are given with impaired renal function.
Pregnancy And Lactation
Based on information available to date for patients with impaired renal function, the initial dose can remain unchanged as can the interval between doses. However, the amount administered as the maintenance dose should be changed according to the following criteria: CrCl 30 ml/min or greater: full dosage CrCl 10-30 ml/min: 50% dosage CrCl <10 ml/min: 25% dosage Use of Pivmecillinam in infants under 3 months of age should be avoided.
Therapeutic
As with other antibiotics, which are excreted mainly by the kidneys, raised blood levels of mecillinam may occur if repeated doses are given with impaired renal function.
Storage Conditions
Based on information available to date for patients with impaired renal function, the initial dose can remain unchanged as can the interval between doses. However, the amount administered as the maintenance dose should be changed according to the following criteria: CrCl 30 ml/min or greater: full dosage CrCl 10-30 ml/min: 50% dosage CrCl <10 ml/min: 25% dosage Use of Pivmecillinam in infants under 3 months of age should be avoided.
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