Provera
IM Injection
Techno Drugs Ltd.Generic:
Medroxyprogesterone AcetateWeight:
150 mg/mlbest Price:
? 45.00Generic
Medroxyprogesterone Acetate
Indications
Medroxyprogesterone Acetate indicated for: Ovulation suppression The treatment of endometriosis. Adjunctive and/or pallivative treatment of recurrent and/or metastatic endometrial or renal carcinoma. The treatment of hormonally-dependant recurrent breast cancer in post-menopausal women.
Pharmacology
Pharmacodynamics: Medroxyprogesterone Acetate injection has prolonged progestational effects when administered by intramuscular injection. This injection suppresses the secretion of pituitary gonadotropins which, in turns, prevents follicular maturation producing long-term anovulation in the reproductive aged women. Medroxyprogesterone Acetate injection suppresses the Leydig cell function in the male. i.e. suppresses endogenous testosterone product. Pharmacokinetics: Parenteral Medroxyprogesterone Acetate is a long acting progestational steroid. The 150 mg/ml formulation reaches half its initial concentration in about 27 days. Its long duration of acting results from its slow absorption from the injection site. The principle metabolite of medroxyprogesterone acetate that has been identified is a 6-alpha-methyl-6 beta 17 alpha, 21 trihydroxy-4-pregnene-3, 20-dione-17 acetate which is excreted in the urine.
Dosage Administration
Ovulation suppression: Medroxyprogesterone Acetate injectables suspension should be gently shaken just before use to ensure that the dose being administered represents a uniform suspension. The recommended dose is 150 mg/ml of this injectable suspension every three months administered by intramuscular injection in the gluteal or deltoid muscle. The initial injection should be given during the first 5 days after the onset of a menstrual period; within the 5 days post partum if not breast feeding; if exclusively breast-feeding at or after six weeks post partum. Based on limited experience, some investigators favour the use of a second injection of Medroxyprogesterone Acetate before 90 days to control troublesome bleeding. The third and subsequent injections should be administered at separate 90 days intervals. If abnormal bleeding persists, appropriate investigations should be instituted to rule out the possibility of organic pathology. Uterine curettage may be required on rare occations.
Contraindications
Aminoglutethimide administered concomitantly with high doses of medroxyprogestrone acetate may significant depress the serum concentration of medroxyprogestrone acetate. User should be warned of the possibility of decreases efficacy with the use of amoniglutethimide.
Side Effects
Female Sex hormones
Pregnancy And Lactation
Keep below 30�C temperature, away from light & moisture. Keep out of the reach of children.
Therapeutic
Female Sex hormones
Storage Conditions
Keep below 30�C temperature, away from light & moisture. Keep out of the reach of children.
Over The Counter Products
