Generic
Naproxen Sodium
Indications
Naproxen is indicated for the relief of sign and symptoms of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, juvenile arthritis, tendonitis, bursitis & acute gout. It is also indicated for the management of primary dysmenorrhea & pain.
Pharmacology
Naproxen is a non steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic & antipyretic properties. It is rapidly absorbed from the gastrointestinal tract and achieves 95% bioavailability.
Dosage Administration
Naproxen Tablet- Rheumatoid arthritis, osteoarthritis and ankylosing spondylitis: The usual dose is 500-1000 mg daily in two divided doses after meals. Management of pain, primary dysmenorrhea, acute tendonitis & bursitis: Recommended starting dose is 500 mg followed by 500 mg every 12 hours or 250 mg every 6-8 hours. The initial total daily dose should not exceed 1250 mg and thereafter, the total daily dose should not exceed 1000 mg. Acute gout: Recommended starting dose is 750 mg followed by 250 mg every 8 hours until the attack has subsided. Naproxen Suspension- For Juvenile rheumatoid arthritis: The usual dose for children over 2 years is 10 mg/kg/day given as two divided doses at 12-hours intervals. Therapy in children under 2 years of age is not recommended. Naproxen Gel- Is to be applied 2-6 times a day as required and is not recommended for use in children.
Contraindications
ACE inhibitors: diminish the antihypertensive effect of ACE inhibitors. Antacids & Sucralfate: delay the absorption of Naproxen. Aspirin: increase adverse effects. Diuretics: reduce the natriuretic effect of Furosemide and Thiazides. Methotrexate: enhance the toxicity of Methotrexate. Warfarin: increase the risk of GI bleeding. Selective Serotonin Reuptake Inhibitors (SSRI): increase the risk of GI bleeding.
Side Effects
Keep below 30�C temperature, protected from light & moisture. Keep out of the reach of children.
Therapeutic
Keep below 30�C temperature, protected from light & moisture. Keep out of the reach of children.
Over The Counter Products
