Procoz
Tablet
Orbit Pharmaceuticals Ltd.Generic:
Prochlorperazine MaleateWeight:
5 mgbest Price:
? 0.30Generic
Prochlorperazine Maleate
Indications
Prochlorperazine Maleate is indicated- To control severe nausea and vomiting caused by radiation therapy, cancer chemotherapy, surgery, and other conditions. Relieving nausea, vomiting, and attacks of dizziness or spinning sensations (vertigo) associated with Meniere's disease and other inner ear disorders. ... Read moreProchlorperazine Maleate is indicated- To control severe nausea and vomiting caused by radiation therapy, cancer chemotherapy, surgery, and other conditions. Relieving nausea, vomiting, and attacks of dizziness or spinning sensations (vertigo) associated with Meniere's disease and other inner ear disorders. For the treatment of psychotic illness such as schizophrenia (hallucinations and hostility). Acute mania. For the short-term treatment of generalized non-psychotic anxiety.
Pharmacology
Prochlorperazine is a dopamine & histamine antagonist. The mechanism of antiemetic activity is due to the blockade of histamine H, & dopamine D2 neurotransmitter receptors in the chemoreceptor trigger zone and vomiting centre. It also has a weak anticholinergic effect and prevents acid reflux by increasing the tone of the lower oesophageal sphincter.
Dosage Administration
Antiemetic- Children (not recommended in children <10 kg or <2 years): 10-14 kg: 2.5 mg every 12-24 hours as needed;maximum: 7.5 mg/day 15-18 kg: 2.5 mg every 8-12 hours as needed;maximum:10 mg/day 19-39 kg: 2.5 mg every 8 hours or 5 mg every 12 hours as needed; maximum: 15 mg/day. Adults: 5-10 mg 3-4 times/day;usual maximum:40 mg/day Antipsychotic- Children (not recommended in children <10 kg or <2 years): 2-12 years: 2.5 mg 2-3 times/day Increase dosage as needed to a maximum daily dose of 20 mg for 2-5 years and 25 mg for 6-12 years Adults: 5-10 mg 3-4 times/day; doses up to 150 mg/day may be required in some patients for treatment of severe disturbances Nonpsychotic anxiety- Adults: Usual dose: 15-20 mg/day in divided doses; do not give doses >20 mg/day or for longer than 12 weeks Elderly: Initial: 2.5-5 mg 1-2 times/day; increase dose at 4 to 7 day intervals by 2.5-5 mg/day; increase dosing intervals (twice daily, thrice daily, etc) as necessary to control response or side effects; maximum daily dose should probably not exceed 75 mg in elderly; gradual increases (titration) may prevent some side effects or decrease their severity. Prochlorperazine may be administered without regard to the meal.
Contraindications
Alcohol, barbiturate & other sedatives may increase the CNS depressant action. Some drugs like Antacids, antiparkinson's drug, lithium may interfere the absorption of Prochlorperazine. This drug may interfere with the plasma concentration of Propanolol and Phenobarbital.
Side Effects
Symptoms of overdose include deep sleep, coma, extrapyramidal symptoms, abnormal involuntary muscle movements, and hypotension.
Pregnancy And Lactation
Anti vertigo drugs, Anti-emetic drugs
Therapeutic
Symptoms of overdose include deep sleep, coma, extrapyramidal symptoms, abnormal involuntary muscle movements, and hypotension.
Storage Conditions
Anti vertigo drugs, Anti-emetic drugs
Over The Counter Products
