Oxaliplatin SANDOZ
IV Infusion
SANDOZ (A Novartis Division)Generic:
OxaliplatinWeight:
5 mg/mlbest Price:
৳3592.90Generic
Oxaliplatin
Indications
Oxaliplatin, used in combination with infusional 5-fluorouracil/leucovorin, is indicated for: Adjuvant treatment of stage III colon cancer in patients who have undergone complete resection of the primary tumor. Treatment of advanced colorectal cancer.
Dosage Administration
Intravenous (Adult)- Adjuvant therapy in stage III colon cancer: In combination with fluorouracil/ leucovorin: 85 mg/m2 every 2 wk for 12 cycles. Dose to be given by IV infusion over 2-6 hr, dissolved in 250-500 ml of glucose 5%, every 2 wk; given for 12 cycles. After recovery from toxicity, reduce dose to 75 mg/m2. Administer before fluoropyrimidines. Advanced colorectal cancer: In combination with fluorouracil/ leucovorin: 85 mg/m2 every 2 wk until disease progression or unacceptable toxicity. Dose to be given by IV infusion over 2-6 hr, dissolved in 250-500 ml of glucose 5%, . After recovery from toxicity, reduce dose to 65 mg/m2. Administer before fluoropyrimidines.
Contraindications
Should be administered under the supervision of an experienced cancer chemotherapy physician. Use appropriate precautions for handling and disposal. Monitor neurological status and dose should be reduced if symptoms are prolonged or severe. Monitor blood counts during treatment and courses should not be repeated until blood counts have recovered. Caution in elderly, moderate degrees of renal impairment. Avoid using aluminum-containing needles or IV admin sets that may come into contact with oxaliplatin as aluminum has been reported to cause degradation of platinum compounds. Lactation.
Side Effects
May decrease plasma levels of digoxin. May increase risk of toxicity with nephrotoxic drugs. When administered as sequential infusions, taxane derivatives (docetaxel, paclitaxel) should be administered before oxaliplatin to limit myelosuppression and enhance efficacy.
Pregnancy And Lactation
Pregnancy. Peripheral neuropathy with functional impairment. Severe renal impairment.
Therapeutic
Store intact vials at 15-30�C; do not freeze. Reconstituted solution: May store at 2-8�C for up to 24 hr. Diluted solutions: Stable up to 6 hr at 20-25�C or up to 24 hr under refrigeration at 2-8�C.
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