Lipiros Tablet
Tablet
Pacific Pharmaceuticals Ltd.Generic:
RosuvastatinWeight:
5 mgbest Price:
৳ 12.50Generic
Rosuvastatin
Pharmacology
Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methyl glutaryl coenzyme A to mevalonate, a precursor of cholesterol. Rosuvastatin produces its lipid-modifying effects in two ways. First, it increases the number of hepatic LDL receptors on the cell surface to enhance uptake and catabolism of LDL. Second, Rosuvastatin inhibits hepatic synthesis of VLDL, which reduces the total number of VLDL and LDL particles.
Dosage Administration
Dose range: 5-40 mg once daily. Use 40 mg dose only for patients not reaching LDL-C goal with 20 mg HoFH: Starting dose 20 mg/day. Pediatric patients with HeFH: 5-10 mg/day for patients 8 to less than 10 years age, and 5-20 mg/day for patients 10 to 17 years of age. Pediatric patients with HoFH: 20 mg/day for patients 7 to 17 years of age.
Contraindications
Rosuvastatin is contraindicated if- Known hypersensitivity to product components Liver disease, which may include unexplained persistent elevations in hepatic transaminase levels Pregnant women and women who may become pregnant Nursing mothers
Side Effects
Rosuvastatin is generally well tolerated. The most frequent adverse events thought to be related to Rosuvastatin were headache, myalgia, constipation, asthenia, abdominal pain and nausea.
Pregnancy And Lactation
The safety in pregnant women has not been established. It is not known whether Rosuvastatin is excreted in human milk or not.
Therapeutic
Other Anti-anginal & Anti-ischaemic drugs, Statins
Storage Conditions
Other Anti-anginal & Anti-ischaemic drugs, Statins
Over The Counter Products
