Generic
Vitamin A
Indications
Illness due to vitamin A deficiency in ophthalmology such as night blindness, xerophthalmia and dermatological such as changes in skin, hair and nails. Concomitant therapy of mucosa illnesses such as sinusitis, bronchitis, in acne vulgaris, ichthyosis, Darier's disease, psoriasis etc. To meet vitmin A demand in growth, resistance to infections and night blindness. This is also indicated to meet vitamin A deficiency after diarrhoea and prophylaxis of measles.
Pharmacology
Beta-carotene, retinol, and retinal have effective and reliable vitamin A activity. Retinal and retinol are in chemical equilibrium in the body and have equivalent antixerophthalmic activity. Retinal combines with the rod pigment, opsin, in the retina to form rhodopsin, necessary for visual dark adaptation. Vitamin A prevents retardation of growth and preserves the epithe-lial cells' integrity. Normal adult liver storage is sufficient to satisfy two years'requirements of vitamin A. Vitamin A is readily absorbed from the gastrointestinal tract, where the biosynthesis of vitamin A from beta-carotene takes place. Vitamin A absorption requires bile salts, pancreatic lipase, and dietary fat. It is transported in the blood to the liver by the chy lomicron fraction of the lymph. Vitamin Ais stored in Kupffer cells of the liver mainly as the palmitate. Normal serum vitamin A is 80-300 Units per 100 mL (plasma range is 30-70 mcg per dl) and for carotenoids 270-753 Units per 100 mL.The normal adult liver contains approximately 100 to 300 micrograms per gram, mostly as retinol palmitate.
Dosage Administration
For Adults: 50000 IU-100000 IU daily up to 200000 IU if necessary. Children (Above 1 year): Night blindness, Bitot's spots, Xerophthalmia: 200000 IU 1st day, 2nd day, 14th day Measles: 200000 IU 1st day, 2nd day Diarrhoea, Respiratory tract infection: 200000 IU every time after disease Severe malnutrition: 200000 IU single-dose or as directed by the registered physician.
Contraindications
Vitamin-A preparations
Side Effects
Keep below 25�C temperature, away from light & moisture. Keep out of the reach of children.
Therapeutic
Keep below 25�C temperature, away from light & moisture. Keep out of the reach of children.
Over The Counter Products
