Generic
Etoposide
Dosage Administration
Intravenous (Adult)- Small cell lung cancer: 35 mg/m2/day for 4 days to 50 mg/m2/day for 5 days. May repeat course at 3-4 wkly intervals after recovery from any toxicity. Inj must be diluted with 5% dextrose or normal saline to give a final concentration of 0.2-0.4 mg/ml and injected over 30-60 minutes. When given via oral capsules: the recommended dose is twice the IV dose rounded to the nearest 50 mg. Testicular cancer: For combination therapy: 50-100 mg/m2/day from days 1-5, or 100 mg/m2 on days 1, 3 and 5. May repeat course at 3-4 wkly intervals after recovery from any toxicity. Inj must be diluted with 5% dextrose or normal saline to give a final concentration of 0.2-0.4 mg/ml and injected over 30-60 minutes. Oral (Adult)- Small cell lung cancer: Twice the IV dose, rounded to the nearest 50 mg.
Contraindications
Hypersensitivity, pregnancy, lactation.
Side Effects
Renal impairment: CrCI: 15-50 ml/min- 75% of the recommended dose.
Pregnancy And Lactation
Pregnancy category D. There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks. Lactation: not known if excreted in breast milk, discontinue drug or do not nurse
Over The Counter Products
