Largazin
Syrup
United Pharmaceuticals Ltd.Generic:
Chlorpromazine HydrochlorideWeight:
25 mg/5 mlbest Price:
? 16.00Generic
Chlorpromazine Hydrochloride
Dosage Administration
Schizophrenia, Psychoses, Anxiety and Agitation Oral- Adult: Initially 25 mg three times daily or 75 mg at bedtime increasing by daily amounts of 25 mg to an effective maintenance dose. This is usually in the range 75 to 300 mg daily, but some patients may require up to 1 g daily. Children: Under 1 Year: Do not use unless need is life saving. 1-5 Years: 0.5 mg/kg bodyweight every 4 - 6 hours to a maximum recommended dose of 40 mg daily. 6-12 Years: A third to half the adult dose, to a maximum recommended dose of 75 mg daily. Elderly: Start with a third to a half the usual adult dose with a more gradual increase in dosage. Intramuscular- Adult: For acute relief of symptoms 25 - 50 mg every 6-8 hours. Children: Under 1 Year: Do not use unless need is life saving. 1-5 Years: 0.5 mg/kg bodyweight every 6 - 8 hours. Dosage is not advised to exceed 40 mg daily. 6-12 Years: 0.5 mg/kg bodyweight every 6-8 hours. Not to exceed 75 mg daily. Elderly: Doses in the lower range for adults should be sufficient to control symptoms, i.e. 25 mg, 8 hourly. Intractable Hiccup (Adult) Oral: 25-50 mg three or four times daily. Intramuscular: 25-50 mg every 6-8 hours. Intravenous Infusion: If other routes of administration are inappropriate, give 25-50 mg in 500-1000 ml sodium chloride by slow intravenous infusion every 6-8 hours. Nausea and Vomiting of Terminal Illness Oral- Adults: 10-25 mg every 4-6 hours. Children: Under 1 Year: Do not use unless need is life saving. 1-5 Years: 0.5 mg/kg every 4 - 6 hours. Maximum daily dosage should not exceed 40 mg. 6-12 Years: 0.5 mg/kg every 4 - 6 hours. Maximum daily dosage should not exceed 75 mg. Elderly: Initially a third to half the adult dose. The physician should then use their clinical judgement to obtain control. Intramuscular- Adults: 25 mg initially, then 25 - 50 mg every 3 - 4 hours until vomiting stops, then drug to be taken orally. Children: Under 1 Year: Do not use unless need is life saving. 1-5 Years: 0.5 mg/kg 6 - 8 hourly. It is advised that maximum daily dosage should not exceed 40 mg. 6-12 Years: 0.5 mg/kg every 6 - 8 hours. It is advised that maximum daily dosage should not exceed 75 mg.
Side Effects
Pregnancy category C. Studies in animals by oral route have shown reproductive toxicity (dose-related embryo fetotoxicity: increased resorptions and dead foetuses). Increased incidence of malformations was observed in mice but only at doses inducing maternal mortality. There is inadequate animal data regarding reproductive toxicity with chlorpromazine by parenteral route. In humans, the teratogenic risk of chlorpromazine has not been evaluated. Different prospective epidemiological studies conducted with other phenothiazines have yielded contradictory results regarding teratogenic risk. Chlorpromazine has been found to be excreted in breast milk in variable amounts, therefore it is not recommended for nursing mothers unless the expected benefits outweigh any potential risk.
Pregnancy And Lactation
Chlorpromazine should never be used in the following circumstances: Circulatory collapse. CNS depression, e.g. coma or drug intoxication. Previous history of a hypersensitivity reaction (e.g. jaundice or blood dyscrasia) to phenothiazines, especially chlorpromazine itself, or to any of the excipients contained in the tablets or injection. Bone marrow depression. Phaeochromocytoma. Hepatic failure or active hepatic disease. Chlorpromazine Injection contains sodium metabisulfite and sodium sulfite and may cause allergic-type reactions including anaphylactic symptoms and asthmatic episodes in susceptible people.
Therapeutic
Elderly: The elderly are relatively more susceptible to the adverse effects of chlorpromazine. The starting dose should be about half the usual adult dose and dosage increments should be gradual and reviewed regularly.
Storage Conditions
Anti-emetic drugs, Phenothiazine drugs, Phenothiazine related drugs
Over The Counter Products
