Laben DS Chewable Tablet
Chewable Tablet
Premier Pharmaceuticals Ltd.Generic:
AlbendazoleWeight:
400 mgbest Price:
৳ 3.52Generic
Albendazole
Indications
Albendazole is indicated in single and mixed infestations of- Hookworm (Ancylostoma, Necator) Roundworm (Ascaris) Threadworm (Enterobius) Whipworm (Trichuris) Strongyloides Tapeworm Opisthorchi Hydatid.
Pharmacology
Albendazole is a benzimidazole anthelmintic, active against most nematodes and some cestodes. It is used in the treatment of intestinal nematode infections and in higher doses in the treatment of hydatid disease. Albendazole exhibits vermicidal, ovicidal, and larvicidal activity. The principal mode of action of Albendazole is its inhibitory effect on tubulin polymerization, which results in the loss of cytoplasmic microtubules.
Dosage Administration
Albendazole is a broad spectrum anthelmintic. Albendazole exhibits vermicidal, ovicidal and larvicidal activities. The drug is thought to exert its anthelmintic effect by blocking glucose uptake in the susceptible helminths, thereby depleting the energy level until it becomes inadequate for survival. Immobilization is followed by the parasite. These events may be a consequence of the binding and subsequent inhibition of parasite tubulin polymerization by Albendazole and its metabolites, although the drug also binds to human tubulin. Albendazole is extensively metabolized, probably in the liver. Albendazole is poorly absorbed from the gastrointestinal tract but rapidly undergoes extensive first-pass metabolism. The principal metabolite albendazole sulphoxide has anthelmintic activity and a plasma half-life of about 8.5 hrs. It is excreted in the urine together with other metabolites.
Side Effects
US FDA Pregnancy category of Albendazole is C. So, Albendazole should be avoided in pregnancy and lactation unless the potential benefits to the other outweigh the possible risks to the fetus.
Pregnancy And Lactation
Neonates: Albendazole is not normally used in neonates. Children: Reduction of the dose from 400 mg to 200 mg may be indicated in children weighing less than 10 kg but there are no grounds for a general reduction in dosage to children. Pregnant woman: Albendazole should not be given during pregnancy or women thought to be pregnant. No information is available on placental transfer. Concurrent disease: There is no evidence to suggest that dose should be altered in renal, hepatic or cardiac failure.
Therapeutic
Anthelmintic
Storage Conditions
Keep in a dry place, away from light and heat. Keep out of the reach of children.
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