G-Ketamine
IM/IV Injection
Gonoshasthaya Pharma Ltd.Generic:
KetamineWeight:
50 mg/mlbest Price:
? 85.00Generic
Ketamine
Pharmacology
Ketamine is a noncompetitive N-methyl-D-aspartate receptor antagonist that blocks glutamate. It has a direct action on the cortex and limbic system. It produces a cataleptic-like state wherein the patient is withdrawn from the surrounding environment.
Dosage Administration
Adult: General Anesthesia- IV Induction: 1-4.5 mg/kg single dose IM Induction: 6.5-13mg IV Infusion: 1-2mg/kg at 0.5mg/kg/min Maintenance: The maintenance dose should be adjusted according to the patient's anesthetic needs and whether an additional anesthetic is employed. Increments of one-half to the full induction dose may be repeated as needed for maintenance of anesthesia. Rapid sequence Intubation, Induction - 2mg/kg IV Pediatric: General Anesthesia: IV Induction: 1-2 mg/kg IV; range: 4-13 mg/kg IM Induction: 5-10 mg/kg; range: 0.5-4.5 mg/kg Maintenance: 0.01-0.03 mg/kg/min continuous IV infusion Maintenance: The maintenance dose should be adjusted according to the patient's anesthetic needs and whether an additional anesthetic is employed. Increments of one-half to the full induction dose may be repeated as needed for maintenance of anesthesia.
Contraindications
CV disease including severe HTN; patients with increased intraocular or CSF pressure.
Side Effects
Emergence reactions (e.g. vivid dreams, hallucinations, confusion, irrational behaviour); increased muscle tone sometimes resembling seizures; temporary HTN and tachycardia, hypotension, bradycardia, arrhythmias, apnoea, laryngospasm, resp depression, diplopia, nystagmus, nausea, vomiting, lacrimation, hypersalivation, raised intraocular and CSF pressure, transient rash and pain at inj site, cystitis.
Pregnancy And Lactation
Pregnancy: The safe use of ketamine in pregnancy has not been established, and such use is not recommended. Lactation: Ketamine is likely to be excreted in breast milk and therefore breastfeeding should be discontinued when ketamine is in use.
Therapeutic
Pregnancy: The safe use of ketamine in pregnancy has not been established, and such use is not recommended. Lactation: Ketamine is likely to be excreted in breast milk and therefore breastfeeding should be discontinued when ketamine is in use.
Storage Conditions
Patient with cardiac decompensation, chronic alcoholic or acutely alcohol-intoxicated patients, pre-anaesth elevated CSF pressure, globe injuries, increased intraocular pressure (e.g. glaucoma), neurotic traits or psychiatric illness (e.g. schizophrenia, acute psychosis), acute intermittent porphyria, seizures, hyperthyroidism, pulmonary or upper resp infection, intracranial mass lesions, head injury, or hydrocephalus, hypovolaemia, dehydration, cardiac disease esp coronary artery disease (e.g. CHF, myocardial ischaemia, MI). Pregnancy and lactation.
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