G-Chloroquine
Syrup
Gonoshasthaya Pharma Ltd.Generic:
Chloroquine PhosphateWeight:
80 mg/5 mlbest Price:
? 14.87Generic
Chloroquine Phosphate
Pharmacology
Chloroquine is used for malarial prophylaxis (as a suppressive) and in managing acute attacks of malaria. It is highly active against erythrocytic forms of P. vivax, P. malariae and P. falciparum. It influences Hb digestion by increasing intravesicular pH in malaria parasite cells and interferes with the nucleoprotein synthesis of the patient. It is also effective in extra intestinal amoebiasis. In RA chloroquine and more effectively hydroxychloroquine have a disease-modifying effect.
Dosage Administration
Treatment of Malaria- Partially immune adults: A single dose of 4 tablets. In severe attacks, the dosage schedule for non-immune adults should be adopted. Partially immune children: Under 1 year: 1-2 single dose (in 5 ml spoonful) 1-3 years: 3-4 single dose (in 5 ml spoonful) 3-6 years: 4-6 single dose (in 5 ml spoonful) 6-9 years: 6-9 single dose (in 5 ml spoonful) In severe attacks, the dosage schedule for non-immune children should be adopted. Non-immune adults: P. falciparum infections: 4 tablets initially, 2 tablets after 6 to 8 hours and then 2 tablets per day for 2 days P. vivax group infections: A single dose of four tablets followed by a course of treatment with primaquine phosphate (15 mg base daily for fourteen days) Non-immune Children: Under 1 year: 1-2 initial dose (in 5 ml spoonful) 1 dose to be taken 6 hours later and then daily for 2 days (in 5 ml spoonful) 1-3 years: 3-4 initial dose (in 5 ml spoonful) 1-2 dose to be taken 6 hours later and then daily for 2 days (in 5 ml spoonful) 3-6 years: 4-6 initial dose (in 5 ml spoonful) 2-3 dose to be taken 6 hours later and then daily for 2 days (in 5 ml spoonful) 6-9 years : 6-9 initial dose (in 5 ml spoonful) 3-5 dose to be taken 6 hours later and then daily for 2 days (in 5 ml spoonful) Prophylaxis and suppression of Malaria- Adults: 2 tablets taken once a week, on the same day each week, during exposure to risk and continued for 6 weeks after leaving the malarious area. Children (Syrup): The following doses should be taken once a week, on the same day each week, during exposure to risk and continued for 6 weeks after leaving the malarious area. Under 1 year: 1 single dose (in 5 ml spoonful) 1-3 years: 2 single dose (in 5 ml spoonful) 3-6 years: 2-3 single dose (in 5 ml spoonful) 6-9 years: 3-5 single dose (in 5 ml spoonful) Children (Tablets): For practical purpose, children over 12 years may be treated as adults and for those below this age, the following proportions may be applied. Under 1 year: ? adult dose (� tablet) 1-4 years: � adult dose (� tablet) 4-8 years: � adult dose (1 tablet) 8-12 years: � adult dose (1.5 tablet)
Contraindications
As with all other drugs, the use of choroquine during pregnancy should be avoided if possible, unless in the case of threatening infections, in the judgment of the physician, when the potential benefit outweighs the risk.
Side Effects
Caution is necessary when giving choroquine to patients with porphyria who also have hepatic dysfunction or cirrhosis as the drug may precipitate severe constitutional symptoms and an increase in the amount of porphyrins excreted in the urine. This reaction is especially apparent in alcoholics. Patients receiving choloquine continuously at higher dose levels for a period longer than 12 months or at weekly intervals for a period of more than 3 years as prophylactic against malaria (or the consumption exceeds 1.6 g/Kg) should undergo ophthalmic examination at three months interval.
Pregnancy And Lactation
Amoebic hepatitis: Four tablets daily for two days followed by one tablet twice daily for two or three weeks. Lupus erythomatosus: One tablet twice daily for one to two weeks followed by a maintenance dose of one tablet daily.
Therapeutic
Amoebic hepatitis: Four tablets daily for two days followed by one tablet twice daily for two or three weeks. Lupus erythomatosus: One tablet twice daily for one to two weeks followed by a maintenance dose of one tablet daily.
Storage Conditions
Anti-malarial drugs
Over The Counter Products
