G Cephalexin Powder for Suspension
Powder for Suspension
Gonoshasthaya Pharma Ltd.Generic:
CephalexinWeight:
125 mg/5 mlbest Price:
৳ 75.00Generic
Cephalexin
Indications
Cephalexin is indicated for the treatment of the following infections when caused by susceptible organisms. Respiratory tract infections: Acute and chronic bronchitis and infected bronchiectasis. Genito-urinary tract infections: Acute and chronic nephritis, cystitis, urethritis and prostatitis, prophylaxis of recurrent urinary tract infections. Skin and soft tissue infections: Caused by staphylococci and/or streptococci. Ear, Nose and Throat infections: Otitis media, mastoiditis, sinusitis, follicular tonsillitis and pharyngitis. Bone infections: Caused by staphylococci and/or P. mirabilis.
Pharmacology
Cephalexin is a semisynthetic analogue of Cephalosporin C. It kills bacteria by interfering in the synthesis of the bacterial cell wall. Peptidoglycan is a heteropolymeric structure that provides the cell wall with mechanical stability. The final stage in the synthesis of peptidoglycan involves the completion of the cross-linking and the terminal glycine residue of the Pentaglycine Bridge is linked to the fourth residue of the pentapeptide (d-alanin). The transpeptidase enzyme that performs this step is inhibited by penicillins and cephalosporins. As a result the bacterial cell wall is weakened, the cell swells and then ruptures. Cephalexin is a first generation cephalosporin that is active by mouth.
Dosage Administration
Adult: The usual dose is 250 mg to 500 mg every 6 hour. For skin and soft tissue infections, streptococcal pharyngitis and uncomplicated cystitis, in patients over 15 years of age: 500 mg of the drug may be administered every 12 hour. In severe or deep seated infections the dose can be increased up to 3 g to 6 g daily. Children: The dosage range is 25-100 mg/kg/day in divided doses to a maximum of 4 g daily Children's Weight Recommended Dose: 10 kg (22 Ibs): 62.5 mg to 125 mg qid or 125 mg to 250 mg bid 20 kg (44 Ibs): 125 mg to 250 mg qid or 250 mg to 500 mg bid 40 kg (88 Ibs): 250 mg to 500 mg qid or 500 mg to 1 g bid For streptococcal pharyngitis, skin and soft tissue infections and in patients over 1 year of age the total daily dose may be divided and administered every 12 hour. In the therapy of otitis media 75-100 mg/kg/day in four divided doses may be required. In the treatment of β haemolytic streptococcal infections a therapeutic dosage of the drug should be given at least for 10 days.
Contraindications
Cefalexin should be given with caution in patients with renal impairment. Under such condition, careful clinical observation should be made because safe dosage may be lower than the usually recommended. The urine of patients receiving Cefalexin may give a false positive reaction for glucose with copper reduction reagent. Positive results to Coombs’ test have been reported. Although there is no evidence of teratogenicity in animal tests, Cefalexin may be used during pregnancy when it is considered essential. Cefalexin is found in the milk of nursing mothers, hence caution should be taken when it is administered to nursing mothers.
Side Effects
First generation Cephalosporins
Pregnancy And Lactation
Should be stored in cool and dry place.
Therapeutic
Should be stored in cool and dry place.
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