Fenex
IM/IV Injection
Techno Drugs Ltd.Generic:
Pheniramine MaleateWeight:
45.5 mg/2 mlbest Price:
? 7.50Generic
Pheniramine Maleate
Pharmacology
Pheniramine competes with histamine for the histamine H1 receptor, acting as an inverse agonist once bound. The reduction in H1 receptor activity is responsible for reduced itching as well as reduced vasodilation and capillary leakage leading to less redness and edema. This can be seen in the suppression of the histamine-induced wheal (swelling) and flare (vasodilation) response. Inverse agonism of the H1 receptor in the CNS is also responsible for the sedation produced by first-generation antihistamines like pheniramine. The binding of pheniramine to H4 receptors, and subsequent inverse agonism, may also contribute to reduced itching by antagonizing inflammation.
Dosage Administration
Allergic conditions including hay fever, drug rashes, angioneurotic edema, serum sickness, allergic conjunctivitis, food allergy etc. Conditions of the respiratory tract that are accompanied by increased secretion, including vasomotor rhinitis and acute rhinitis. ... Read more
Contraindications
Patients with hypersensitivity to pheniramine or any other ingredient (eg. Methyl hydroxybenzoate or propyl hydroxybenzoate in the syrup). Patients with symptomatic prostatic hypertrophy. Patients receiving MAO-inhibitor therapy. Newborn and premature infants.
Side Effects
The most common adverse reaction is sedation, which often disappears after a few days if tolerance is acquired. Hypersensitivity reactions have been reported. Central Nervous System: Lassitude, dizziness, tinnitus, inability to concentrate, incoordination, irritability, insomnia and tremors. Agitation and convulsions, especially in children and restlessness, disorientation and hallucinations in adults, are common symptoms following overdose. Gastrointestinal: Nausea, vomiting, diarrhoea, colic, epigastric pain, anorexia, dryness of mouth and constipation. Genitourinary: Urinary retention. Cardiovascular: Palpitations, headache. Ocular: Blurred vision, increased intraocular pressure. Musculoskeletal: Muscular weakness. Haematological: Rare cases of blood dyscrasias including agranulocytosis and haemolytic anaemia have been reported.
Pregnancy And Lactation
pregnancy Category A. Use only if strictly indicated. Use only if strictly indicated.
Therapeutic
Sedating Anti-histamine
Storage Conditions
Store in a cool and dry place, protected from light. Do not use later than the date of expiry. Keep all medicines out of the reach of children. To be dispensed only on the prescription of a registered physician.
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