Generic
Favipiravir
Pharmacology
Favipiravir is a new antiviral drug against influenza. It is metabolized into favipiravir ribosyl triphosphate (favipiravir RTP) by an intracellular enzyme, and favipiravir RTP selectively inhibits RNA polymerase (RNA-dependent RNA polymerase) of the influenza virus, preventing replication of the influenza virus. It is a drug with a mechanism of action different from that of the existing influenza antiviral drugs and effective against all types and sub-types of human influenza A, B, and C viruses in vitro, showing a wide range of anti-viral activity against various influenza virus strains including avian and swine viruses.
Contraindications
Favipiravir is contraindicated for pregnant women and women who may possibly be pregnant.
Side Effects
Most common side effects are Diarrhea and increase of blood uric acid levels.
Pregnancy And Lactation
Favipiravir may cause delayed development or death of embryos during the early stage of pregnancy. Should not be given during pregnancy.
Therapeutic
In animal studies, decreased RBC production,and increases in liver function parameters such as AST, ALP, ALT and total bilirubin, and increased vacuolization in hepatocytes. Toxicity information regarding Favipiravir in humans is not readily available.
Storage Conditions
Anti-viral drugs
Over The Counter Products
