Generic
Etoposide
Indications
Small Cell Lung Cancer: Etoposide Capsules in combination with other approved chemotherapeutic agents as first line treatment in patients with small cell lung cancer. Etoposide is also indicated in Testicular cancer, Small cell lung cancer
Pharmacology
Etoposide is a derivative of podophyllotoxin that inhibits DNA synthesis resulting in the arrest of the cell cycle. At low doses, it inhibits cells from entering cell cycle and at high doses, cells entering mitosis are lysed.
Contraindications
Skin reactions may occur with accidental exposure; renal or hepatic disease. Periodic CBCs should be done before, during and after therapy. Increased risk of etoposide-toxicity in patients with low serum albumin. Acrylic material has been shown to crack and leak when used with undiluted etoposide inj.
Side Effects
Renal impairment: CrCI: 15-50 ml/min- 75% of the recommended dose.
Pregnancy And Lactation
Pregnancy category D. There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks. Lactation: not known if excreted in breast milk, discontinue drug or do not nurse
Therapeutic
Skin reactions may occur with accidental exposure; renal or hepatic disease. Periodic CBCs should be done before, during and after therapy. Increased risk of etoposide-toxicity in patients with low serum albumin. Acrylic material has been shown to crack and leak when used with undiluted etoposide inj.
Storage Conditions
Renal impairment: CrCI: 15-50 ml/min- 75% of the recommended dose.
Over The Counter Products
