Epleron Tablet
Tablet
Incepta Pharmaceuticals Ltd.Generic:
EplerenoneWeight:
25 mgbest Price:
৳ 30.00Generic
Eplerenone
Indications
Congestive heart failure after an acute myocardial infarction, Hypertension.
Pharmacology
Eplerenone selectively binds to the mineralocorticoid receptor and blocks the binding of aldosterone, a key component in the renin-angiotensin-aldosterone-system, which is involved in the regulation of BP and pathophysiology of CV disease. Aldosterone binds to mineralocorticoid receptors in both epithelial (e.g. kidney, GI tract) and nonepithelial (e.g. heart, blood vessels, brain) tissues; causing increases in BP by inducing Na reabsorption, vascular remodelling, water retention, endothelial dysfunction and possibly other mechanisms.
Contraindications
Eplerenone should be used with caution in hyperkalemia, severe kidney disease, diabetic patients with congestive heart failure after an acute myocardial infarction including those with proteinuria.
Side Effects
Pediatric use: The safety and effectiveness of Eplerenone has not been established in pediatric patients. Geriatric use: No differences in overall incidence of effectivity or safety was observed in elderly patients.
Pregnancy And Lactation
Pregnancy: There are no adequate and well-controlled studies in pregnant women. Eplerenone should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Lactation: The concentration of Eplerenone in human breast milk after oral administration is unknown. Because many drugs are excreted in human milk and because of the unknown potential for adverse effects on the nursing infant, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
Therapeutic
Eplerenone should be used with caution in hyperkalemia, severe kidney disease, diabetic patients with congestive heart failure after an acute myocardial infarction including those with proteinuria.
Storage Conditions
Pediatric use: The safety and effectiveness of Eplerenone has not been established in pediatric patients. Geriatric use: No differences in overall incidence of effectivity or safety was observed in elderly patients.
Over The Counter Products
