Entroza Tablet
Tablet
Incepta Pharmaceuticals Ltd.Generic:
AnastrozoleWeight:
1 mgbest Price:
৳ 50.00Generic
Anastrozole
Indications
Anastrozole is indicated in- Treatment of early breast cancer in hormone receptor positive post-menopausal women. Adjuvant treatment of early breast cancer in hormone receptor positive postmenopausal women who have received 2 to 3 years of adjuvant tamoxifen. Reduction in the incidence of contralateral breast cancers in post menopausal women receiving Anastrozole as adjuvant treatment for early breast cancer. Treatment of advanced breast cancer in post-menopausal women.
Pharmacology
Anastrozole tablet is a potent and highly selective nonsteroidal aromatase inhibitor. Anastrozole selectively inhibits the conversion of androgens to estrogens, without affecting synthesis of adrenal corticosteroid, aldosterone or thyroid hormone. Suppression of estrogen biosynthesis in all tissues reduces serum concentrations of circulating estrogens, including estrone, estradiol, and estrone sulphate with a subsequent beneficial effect in breast cancer.
Dosage Administration
Adults Including the Elderly: One tablet (1 mg) to be taken orally once a day. Children: The use of Anastrozole is not recommended in children, as efficacy has not been established Renal Impairment: No dose change is recommended. Hepatic Impairment: No dose change is recommended.
Contraindications
Anastrozole is not recommended for use in children or in pre-menopausal women as safety and efficacy have not been established in these groups of patients. Anastrozole has not been investigated in patients with severe hepatic or severe renal impairment. The potential risk/benefit to such patients should be carefully considered before administration of Anastrozole. As Anastrozole lowers circulating estrogen levels, it may cause a reduction in bone mineral density with a possible consequent increased risk of fracture.
Side Effects
There is limited clinical experience of overdose of Anastrozole. There are no reports where a patient has taken a dose in excess of 60 mg. No toxicity was observed and no clinically relevant adverse effects have been seen.
Pregnancy And Lactation
Anastrozole must not be administered during pregnancy or lactation.
Therapeutic
Anastrozole is not recommended for use in children or in pre-menopausal women as safety and efficacy have not been established in these groups of patients. Anastrozole has not been investigated in patients with severe hepatic or severe renal impairment. The potential risk/benefit to such patients should be carefully considered before administration of Anastrozole. As Anastrozole lowers circulating estrogen levels, it may cause a reduction in bone mineral density with a possible consequent increased risk of fracture.
Storage Conditions
There is limited clinical experience of overdose of Anastrozole. There are no reports where a patient has taken a dose in excess of 60 mg. No toxicity was observed and no clinically relevant adverse effects have been seen.
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