Generic
Midazolam
Indications
Midazolam is indicated in- Short-term treatment of insomnia. Sedation in premedication before surgical or diagnostic procedures.
Pharmacology
Midazolam is a sleep-inducing agent characterized by a rapid onset and short duration of action. It also exerts an anxiolytic, anticonvulsant and muscle-relaxant effect.
Contraindications
Midazolam can enhance the central sedative effect of neuroleptics, tranquillizers, antidepressants, sleep-inducing drugs, analgesics, anaesthetics, antipsychotics, anxiolytics, antiepileptic drugs and sedative antihistamines.
Side Effects
Midazolam IV should be administered very slowly.
Pregnancy And Lactation
At the start of therapy, drowsiness during daytime, confusion, fatigue, headache and muscle weakness may occur which usually disappear with repeated administration. Following parenteral (IV or IM) administration of Midazolam, fluctuations in vital signs have been noted including respiratory depression, apnea, variations in blood pressure and pulse rate.
Therapeutic
Extreme overdosage may lead to coma, areflexia, cardiorespiratory depression and apnea. The effects of overdosage can be controlled with benzodiazepine antagonist flumazenil.
Storage Conditions
Benzodiazepine hypnotics, Benzodiazepine sedatives
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