Diacana
Tablet
NIPRO JMI Pharma Ltd.Generic:
Canagliflozin HemihydrateWeight:
100 mgbest Price:
? 60.00Generic
Canagliflozin Hemihydrate
Pharmacology
Canagliflozin is an inhibitor of subtype-2 sodium-glucose co-transport protein (SGLT2), which is responsible for at least 90% of the glucose reabsorption in the kidney. Blocking this transporter reduces the reabsorption of glucose from renal tubules, leading to more excretion of glucose in urine.
Dosage Administration
The recommended starting dose is 100 mg once daily, taken before the first meal of the day. Dose can be increased to 300 mg once daily who have CrCl>60 ml/min or who requires additional glycemic control. No dose adjustment is required for mild renal impairment. For moderate renal impairment (CrCl 45-60 ml/min) Canagliflozin 100 mg is recommended.
Contraindications
History of serious hypersensitivity reaction to Canagliflozin, severe renal impairment, End Stage Renal Disease (ESRD), or on dialysis patients.
Side Effects
The most common adverse reactions of Canagliflozin are female genital mycotic infections, urinary tract infection and increased urination. Other side effects of Canagliflozin include low blood pressure, increases potassium blood levels (hyperkalemia), low blood glucose and increases Low-Density Lipoprotein (LDL-C).
Pregnancy And Lactation
Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. For nursing mother discontinue drug or nursing.
Therapeutic
Not for the treatment of type 1 diabetes mellitus or diabetic ketoacidosis.
Storage Conditions
Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors
Over The Counter Products
