Dantron Oral Solution
Oral Solution
One Pharma Ltd.Generic:
OndansetronWeight:
4 mg/5 mlbest Price:
৳ 40.00Generic
Ondansetron
Pharmacology
Ondansetron oral soluble film is a orally dissolving film designed to be applied on top of the tongue where it will dissolve within 20 seconds and then is swallowed with saliva. Oral soluble film does not require water to aid dissolution or swallowing. The active ingredient in this preparation is ondansetron base, the racemic form of ondansetron, and a selective blocking agent of the serotonin 5-HT3 receptor type. The empirical formula is C18H19N3O representing a molecular weight of 293.3.
Contraindications
Administration of Oral Soluble Film: Step 1: Tear the pouch carefully along with the edge tear mark. Step 2: Put the Ondansetron film on top of your tongue. It will dissolve within 20 seconds Step 3: Do not chew or swallow the film whole. Step 4: Swallow after the Onsaf oral soluble film dissolves. You may swallow the dissolved film with or without liquid. Step 5: Wash your hands after taking Onsaf oral soluble film
Pregnancy And Lactation
Ondansetron does not itself appear to induce or inhibit the cytochrome P-450 drug-metabolizing enzyme system of the liver. Because Ondansetron is metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes, inducers or inhibitors of these enzymes may change the clearance and hence, the half-life of Ondansetron. On the basis of available data, no dosage adjustment of Ondasetron is recommended for patients on these drugs.
Therapeutic
Hypersensitivity reactions have been reported in patients who have exhibited hypersensitivity to other selective 5-HT3 receptor antagonists. Ondansetron is not a drug that stimulates gastric or intestinal peristalsis. It should not be used instead of nasogastric suction. The use of Ondansetron in patients following abdominal surgery or in patients with chemotherapy-induced nausea and vomiting may mask a progressive ileus and/or gastric distension.
Storage Conditions
Dosage Adjustment for Patients With Impaired Renal Function: The dosage recommendation is the same as for the general population. Dosage Adjustment for Patients With Impaired Hepatic Function: In patients with severe hepatic impairment, a single maximal daily dose of 8 mg to be infused over 15 minutes beginning 30 minutes before the start of the emetogenic chemotherapy is recommended. 4 years of age or younger: Little information is available about dosage in pediatric patients 4 years of age or younger. Over the age of 65: Dosage adjustment is not needed in patients over the age of 65.
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