D-Dopamine
IV Injection
Drug International Ltd.Generic:
Dopamine HydrochlorideWeight:
200 mg/5 mlbest Price:
? 45.15Generic
Dopamine Hydrochloride
Contraindications
The action of dopamine hydrochloride is potentiated by monoamine oxidase inhibitors (MAOI's). The concurrent administration of cyclopropane or halogenated hydrocarbon anesthetics may cause ventricular arrhythmias. The cardiac effects of dopamine hydrochloride are antagonized by ? - adrenergic blocking agents such as Propranolol and Metoprolol. The ergot alkaloids should be avoided because of the possibility of excessive vasoconstriction. Tricyclic antidepressants and guanethidine may potentiate the pressor response to dopamine hydrochloride. Hypotension and bradycardia have been observed in patients receiving Phenytoin. Dopamine hydrochloride may increase the effect of diuretic agents. Peripheral vasoconstriction may be antagonized by ? - adrenergic blocking agents, such as Phentolamine. Other vasodilators may also be useful in patients with heart failure, allowing greater inotropic and renal effects without the associated vasoconstriction. Care must be taken to avoid hypotension.
Side Effects
Dopamine hydrochloride is contraindicated in patients with known hypersensitivity to dopamine or any of its ingredients. It should not be used in patients with phaeochromocytoma, uncorrected tachyarrhythmias, or ventricular fibrillation. Dextrose solution without electrolytes should not be administered simultaneously with blood through the same infusion set because of the possibility of pseudoagglutination of red cells.
Pregnancy And Lactation
The most frequent reported adverse reactions are ectopic beats, nausea, vomiting, tachycardia, anginal pain, palpitations, dyspnoea, headache, hypotension, hypertension and vasoconstriction. Other less frequent adverse reactions are aberrant ventricular conduction, bradycardia, piloerection, mydriasis, widened QRS complex, azotaemia and elevated blood pressure. Peripheral ischemic gangrene in patients with pre-existing vascular disease. Fatal ventricular arrhythmias have been reported on rare occasions.
Therapeutic
Inotropic-sympathomimetics
Storage Conditions
Dopamine hydrochloride must be diluted before administration to patients. Transfer contents of one or more ampoules by aseptic technique to either 250 ml or 500 ml of one of the following sterile intravenous solutions: 0.9% Sodium Chloride, 5% Dextrose, 5% Dextrose and 0.9% Sodium Chloride, 5% Dextrose in 0.45% Sodium Chloride, 5% Dextrose in Ringer's Lactate, Sodium Lactate (1/6 Molar), Ringer's Lactate. Dopamine hydrochloride has been found to be stable for a minimum of 24 hours after dilution in the sterile intravenous solutions listed above. However, as with all intravenous admixtures, dilution should be made just prior to administration. Do not add dopamine hydrochloride solution to sodium bicarbonate or other alkaline intravenous solutions, since the drug is inactivated in alkaline solution. Mixing of dopamine hydrochloride with alteplase in the same container should be avoided as visible particulate matter has been observed. It is recommended that dopamine should not be added to amphotericin B solution because amphotericin B is physically unstable in dopamine-containing solutions.
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