Generic
Erythromycin
Indications
Erythromycin is highly effective in the treatment of a wide variety of clinical infections. Upper respiratory tract infections: Tonsilitis, Peritonsillar abscess, Pharyngitis, laryngitis, Sinusitis. Secondary infections in colds and influenza. Lower respiratory tract infections: Tracheitis, acute and chronic bronchitis. Ear infections: Otitis media, otitis externa, mastoiditis. Eye infections: Blepharitis, established trachoma. Skin and Soft tissue infections: Boils and carbuncles, impetigo, abscesses, pustular acne, paromychia, cellulitis, erysipelas. Gastrointestinal tract infections: Cholecystitis, staphylococcal enterocolitis. Prophylaxis: Pre and post-operative, trauma, burns, rheumatic fever. Other infections: Osteomyelitis, diptheria, scarlet fever, whooping cough.
Pharmacology
Erythromycin belongs to the macrolides group of antibiotics. It exerts a bacteriostatic or bactericidal action based on specific interference with ribosomal protein synthesis within the bacterial cell. THROCIN is mainly used for the treatment of infections caused by penicillinase producing staphylococci. The following micro-organisms are particularly susceptible to Erythromycin. Gram (+)ve : Cocci and bacilli. Gram (-)ve : Neisseria catarhalis, N.meningitis, N.gonorrhoea, Haemophilus influenzae, Brodetella, H. pertussis.Other micro-organisms : Mycoplasma pneumoniae, Legionella pneumophila, Bacteroides fragilis, B.oralis, B.melaninogenicus, Fusobacterium, Chlamydia trachomatis, Treponema pallidum.
Contraindications
Recent data from studies of erythromycin reveals that its use in patients who are receiving high dosage of theophylline may be associated with an increase of serum theophylline levels and potential theophylline toxicity. In such cases this dose of theophylline should be reduced.
Side Effects
Known hypersensitivity to Erythromycin.
Pregnancy And Lactation
Allergic reactions are rare and mild although anaphylaxis has occurred. Occasionally there is abdominal discomfort after oral administration, sometimes with nausea and vomiting. This discomfort usually subsides after a few days without it being necessary to reduce the dosage.
Therapeutic
Erythromycin should be given with care in patients with impaired hepatic function, as erythromycin is excreted principally in the bile.
Storage Conditions
In case of overdosage, Erythromycin should be discontinued. Overdosage should be handled with the prompt elimination of unabsorbed drug and all other appropriate measures should be instituted. Erythromycin is not removed by peritoneal dialysis or haemodialysis.
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