Convules SR Tablet (Controlled Release)
Tablet (Controlled Release)
Opsonin Pharma Ltd.Generic:
Sodium ValproateWeight:
300 mgbest Price:
৳ 6.04Generic
Sodium Valproate
Indications
Sodium Vaiproate oral is indicated for the treatment of all types of epilepsy, e.g. Partial seizures Absence seizures (petit mal) Generalized tonic-clonic seizures (grand mal) Myoclonic seizures Atonic seizures Mixed seizures that include absence attack ... Read moreSodium Vaiproate oral is indicated for the treatment of all types of epilepsy, e.g. Partial seizures Absence seizures (petit mal) Generalized tonic-clonic seizures (grand mal) Myoclonic seizures Atonic seizures Mixed seizures that include absence attack Prophylaxis of febrile convulsion Prophylaxis of post-traumatic epilepsy. It is also indicated in the treatment of bipolar disorder & prophylaxis of migraine.
Pharmacology
Sodium Valproate tablet: Each enteric-coated tablet contains Sodium Valproate BP 200 mg. Sodium Valproate syrup: Each 5 ml syrup contains Sodium Valproate BP 200 mg. Sodium Valproate controlled release 200 tablet: Each enteric-coated controlled release tablet contains Sodium Valproate 200 mg as Sodium Valproate BP 133.2 mg & Valproic acid BP 58 mg. Sodium Valproate controlled release 300 tablet: Each enteric-coated controlled release tablet contains Sodium Valproate 300 mg as Sodium Valproate BP 199.8 mg & Valproic acid BP 87 mg. Sodium Valproate controlled release 500 tablet: Each enteric-coated controlled release tablet contains Sodium Valproate 500 mg as Sodium Valproate BP 333 mg & Valproic acid BP 145 mg.
Contraindications
Sodium Vaiproate appears to act as a non specific inhibitor of drug metabolism. Drugs to which it interacts most significantly are Phenobarbital, Phenytoin, Warfarin, Aspirin etc.
Side Effects
Sodium Valproate is contraindicated to patients who have known hypersensitivity to the drug and liver dysfunction. Use of Sodium Valproate is restricted during pregnancy and in women of childbearing potential.
Pregnancy And Lactation
The most common side effects are anorexia, nausea and vomiting. However, these side effects are minimized with the use of enteric coated tablets. Effects on the CNS include sedation, ataxia and tremor. These symptoms occur infrequently and usually respond to a decrease in doses. Rash, alopecia and stimulation of appetite have been observed occasionally. Sodium Vaiproate has several effects on hepatic function of which elevation of liver enzymes in plasma is observed in up to 40% of patients and often occurs asymptomatically during the first few months of therapy. Rarely a fulminate hepatitis that may be fatal may develop. Children below 2 years of age with other medical conditions and those being treated with multiple antiepileptic agents are specially prone to suffer from hepatic injury, acute pancreatitis and hyperammonemia have also been frequently associated with the use of Sodium Valproate.
Therapeutic
Liver functions should be monitored before therapy and during first 6 months especially in patients most at risk, No undue potential for bleeding before starting and before major surgery must be ensured, Care should be taken in renal impairment, pregnancy, breast-feeding and systemic lupus erythematosus. Sodium Valproate is partially eliminated in the urine as a ketone metabolite, which may lead to a false interpretation of the urine ketone test. Sudden withdrawal of therapy should be avoided. Sodium Valproate should not be used during pregnancy and in women of childbearing potential.
Storage Conditions
Primary anti-epileptic drugs
Over The Counter Products
