Cizin Syrup
Syrup
Nipa Pharmaceuticals Ltd.Generic:
Cetirizine HydrochlorideWeight:
5 mg/5 mlbest Price:
৳ 15.17Generic
Cetirizine Hydrochloride
Indications
It is indicated for the relief of symptoms associated with seasonal & perennial allergic rhinitis. It is also indicated for the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria and allergen induced asthma.
Pharmacology
Cetirizine Hydrochloride is a potent H1 receptor antagonist without any significant anticholinergic and antiserotonic effects. At pharmacologically active dose levels, it has almost no drowsiness effect and does not cause behavioral changes. It inhibits the histamine-mediated early phase of the allergic reaction and also reduces the migration of inflammatory cells and the release of mediators associated with the late phase of the allergic reaction. Pharmacokinetics: Cetirizine 10 mg achieves peak plasma concentrations of 257 mcg/L within one hour of administration (980 mcg/L in children). Food does not affect the extent of absorption, but it may slightly reduce the rate. Peak blood levels 0.3 micrograms/ml are reached between thirty & sixty minutes after administration of 10 mg dose of Cetirizine. Its plasma half-life is approximately 11 hours. Absorption is very consistent from one subject to the next. Its renal clearance is 30 ml/minute and the excretion half-life is approximately nine hours.
Dosage Administration
Adults and Children 6 years and older: 1 tablet or 2 teaspoonfuls daily (or 1 teaspoonful twice daily). Children 2-6 years: 1 teaspoonful once daily or 1/2 teaspoonful twice daily. Children 6 months to 2 years : 1/2 teaspoonful once daily. The dose in children 12-23 months of age can be increased to a maximum dose as 1/2 teaspoonful every 12 hours.
Contraindications
Caution should be exercised when driving a car or operating a heavy machinery.
Side Effects
Caution should be exercised when driving a car or operating a heavy machinery.
Pregnancy And Lactation
The most common side effects that occurred more frequently on Cetirizine is somnolence.
Therapeutic
Keep in a dry place away from light and heat. Keep out of the reach of children.
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