Calcitonin
Injection
City Overseas Ltd.Generic:
Salmon CalcitoninWeight:
100 IU/mlbest Price:
? 145.00Generic
Salmon Calcitonin
Indications
Salmon Calcitonin is indicated in Active Paget's disease in patients who do not respond to alternative treatments or for whom such treatments are not suitable; Hypercalcaemia.
Pharmacology
Each ml Salmon Calcitonin injection contains- 50 or 100 I.U. salcatonin (present as Polyacetate polyhydrate) Sodium acetate 0.2% Glacial acetic acid 0.2% Sodium chloride 0.75% Salmon Calcitonin contains 32 amino-acids in linear sequence with a disulphide bridge at position 1 and 7 and a molecular weight of 3431.9 (free peptide). Salcatonin is a white or grey-tinged white amorphous powder. It is very soluble in water and very slightly soluble in alcohol.
Dosage Administration
Calcitonin is a polypeptide hormone produced by the ultimobranchial gland in non-mammalian vertebrates or by the mammalian thyroid parafollicular cells. It inhibits osteoclastic bone resorption and reduces bone turnover. It decreases tubular reabsorption and promotes renal excretion of Ca, Cl, Na, Mg, K and phosphate.
Side Effects
Concurrent use wth cardiac glycosides (e.g. digitalis) or Ca-channel blockers requires dosage adjustments of these drugs. May decrease serum concentration of lithium.
Pregnancy And Lactation
Hypersensitivity. Patients with hypocalcaemia.
Therapeutic
Pregnancy Category C. Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Storage Conditions
Symptoms: Flushing, nausea, vomiting and dizziness. Management: Symptomatic and supportive treatment.
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