Biocef Capsule
Capsule
SANDOZ (A Novartis Division)Generic:
Cefaclor MonohydrateWeight:
500 mgbest Price:
৳ 46.50Generic
Cefaclor Monohydrate
Indications
Cefaclor is indicated in the treatment of the following infections: Otitis media, Lower respiratory tract infections, including pneumonia, bronchitis and acute exacerbation of chronic bronchitis, Upper respiratory tract infections, including pharyngitis and tonsillitis, Urinary tract infections, including pyelonephritis and cystitis, Skin and soft tissue infections, Sinusitis
Pharmacology
Cefaclor is a second generation cephalosporin antibiotic which has stability against b-lactamase inactivation and possesses a broad spectrum of activity. Cefaclor is active against the following organisms in vitro: Alpha and beta haemolytic Streptococci, Staphylococci; including coagulase-positive, coagulase negative and penicillinase-producing strains, Streptococcus pneumoniae, Streptococcus pyogenes (Group A b-haemolytic Streptococci), Branhamella catarrhalis, Escherichia coli, Proteus mirabilis, Klebsiella species Haemophilus influenzae, including ampicillin-resistant strains. Cefaclor is generally effective in the eradication of Streptococci from the nasopharynx.
Dosage Administration
Adult- Usual dose: 250 mg 8 hrly. Bronchitis & pneumonia: 250 mg tid. Sinusitis: 500 mg tid for 10 days. Pneumonia & other more severe infections: Max: 4 gm/day for 28 days. Acute gonococcal urethritis: 3 gm as a single dose combined with probenecid 1 gm. Children- Recommended dose: 20 mg/kg/day in divided doses 8 hrly. Bronchitis & pneumonia: 20 mg/kg/day in divided doses tid. Serious infections, sinusitis, otitis media & infections: caused by less susceptible organisms 40 mg/kg/day in divided doses. Max: 1 gm/day.
Pregnancy And Lactation
Cefaclor is contraindicated in patients with known allergy to the Cephalosporin group of antibiotics.
Therapeutic
There are no adequate and well-controlled studies in pregnant women. This drug should be used during pregnancy only if clearly needed. Small amounts of Cefaclor have been detected in mother's milk. The effect on nursing infants is not known. Caution should be exercised when Cefaclor is administered to a nursing woman.
Storage Conditions
Cefaclor should be administered with caution in the presence of markedly impaired renal function. Dosage adjustments for patients with moderate or severe renal impairment are not usually required.
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