Generic
Povidone Iodine
Indications
Cream or ointment: Therapeutically: As an adjunct to systemic therapy in the following indications- Primary or secondary topical infections Infected surgical incisions Infected decubitus or stasis ulcers Pyodermas Secondarily infected dermatoses ... Read moreCream or ointment: Therapeutically: As an adjunct to systemic therapy in the following indications- Primary or secondary topical infections Infected surgical incisions Infected decubitus or stasis ulcers Pyodermas Secondarily infected dermatoses Infected traumatic lesions Prophylactically: To prevent microbial contaminations in burns, incisions and other topical lesions For degerming skin in hyperalimentation, the umbilical area or circumcision Its use for abrasions, minor cuts, and wounds prevents the development of infections and permits wound healing. Solution: For the prevention and treatment of surface infections as well as to degerm the skin, mucous membrane and hyperalimentation procedures For seborrhea For preoperative and postoperative scrubbing and washing of hospital operating room and equipments For preoperative prepping of operative site, including the vagina For disinfection of wounds, burns, lacerations and abrasions As a prophylactic anti-infective agent in house, hospital & office procedures Postoperative application to incisions to help prevent infection In oral moniliasis (thrush); bacterial and mycotic skin infections, decubitus & stasis ulcers As a preoperative swab in the mouth & throat Gargle & Mouthwash: It is a pleasantly flavoured solution which is used: For the treatment of acute mucosal infections of the mouth and pharynx. For oral hygiene prior to, during and after dental and oral surgery. Surgical Scrub: It is a golden surfactant solution, forms rich, golden lather which is used: As an antiseptic skin cleanser for preoperative and postoperative scrubbing and washing by surgeons and operation theatre staff and preoperative preparation of patients' skin Powder: It is used for topical application in the following indications: Superficial wounds, Minor cuts, Burns, Abrasions, Lacerations, In the treatment and prevention of infections. Ophthalmic Solution: Povidone is used for the symptomatic treatment of dry eye conditions including keratoconjunctivitis sicca. It is also given as a substitute for tear fluid in case of the unstable tear film or insufficient moistening of the eye surface.
Pharmacology
Povidone Iodine is a complex of iodine and an organic polymer, povidone. This polymerization makes Povidone Iodine superior to ordinary elemental iodine. It prolongs the germicidal activity of iodine by liberating elemental iodine slowly. Consequently it has a lower toxicity than elemental iodine. It gives rapid microbicidal activity against both Gram-positive and Gram-negative bacteria, protozoa, viruses and fungi/yeasts. It is also sporicidal. It is the only microbicide with this broad spectrum of activity. It is non-staining, exerts prolong germicidal action and is also active in the presence of soap, blood, serum, pus, mucosal secretions and water.
Dosage Administration
Cream or ointment: For the treatment of infection: Apply once or twice daily or at dressing changes for a maximum of 14 days. For the prevention of infection: Apply once or twice a week for as long as necessary. The affected skin should be cleaned and dried and can be covered with a dressing or bandage. Solution: Apply full strength as often as needed as paint, spray, or wet soak. Maybe bandaged (where necessary). Gargle & Mouthwash: Adults and children over 6 years of age: Use undiluted or diluted with an equal volume of warm water. Gargle or rinse with up to 10 mL for up to 30 seconds without swallowing. Repeat up to four times daily, for up to 14 consecutive days, or as advised by the Registered Dental Surgeon/Physician. Surgical Scrub: For Preoperative and Postoperative washing by Operating Personnel: Wet hands and forearms with water. Pour about 5 mL of Povidone Iodine Surgical Scrub on the palm of the hand and spread over both hands and forearms. Without adding more water, rub the Scrub thoroughly over all areas for about five minutes. Use a brush if desired. Clean thoroughly under fingernails. Add a little water and develop copious suds. Rinse thoroughly under running water. Complete the wash by scrubbing with another 5 mL of Povidone Iodine Surgical Scrub in the same way. For Preoperative use on Patients: After the skin area is shaved, wet it with water. Apply Povidone Iodine Surgical Scrub (1 mL is sufficient to cover an area of 20-30 square inches), develop lather and scrub thoroughly for about five minutes. Rinse off by aid of sterile gauze saturated with water. For use in the Physician's Office: Use for washing whenever a germicidal soap is required. Powder: Apply a light dusting of powder to the affected area. When dry, this forms a protective antiseptic layer over the area treated. Or use as advised by the Registered Physician. There are no special dosage recommendations for children or elderly patients. Ophthalmic Solution: 1 drop 4 times daily or as required, depending upon the severity of the disease, to be instilled into the conjunctival sac.
Contraindications
It can cause hypersensitivity reactions. Regular use in patients with thyroid disorders (in particular nodular colloid goitre, endemic goitre and Hashimoto's thyroiditis) or those receiving lithium therapy is to be avoided. In severely burnt patients serum iodide levels should be assessed due to possible hepatic and renal impairment. Povidone Iodine Powder should not be used in serious cavities and in Children under the age of 2 years.
Side Effects
Povidone Iodine may cause hypersensitivity reactions and irritation of the skin and mucous membranes. The application of povidone Iodine to severe burns or to large areas otherwise denuded of skin may produce systemic adverse effects such as metabolic acidosis, hypernatraemia, and impairment of renal function. It may interfere with thyroid function tests.
Pregnancy And Lactation
Povidone Iodine Cream, Solution & Powder are not recommended for use during pregnancy because of the possibility of absorption of sufficient iodine to affect the fetal thyroid. American Academy of Pediatrics considers that the use of Povidone-Iodine is usually compatible with breast feeding. Consult Registered Physician. Regular use of Gargle & Mouthwash and Surgical Scrub should also be avoided in pregnant and lactating women. There is no experience regarding the safety of the Povidone eye drops in human pregnancy or lactation. Administration during pregnancy and lactation is therefore not recommended, except for compelling reasons.
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