Generic
Anastrozole
Indications
Anastrozole is indicated in- Treatment of early breast cancer in hormone receptor positive post-menopausal women. Adjuvant treatment of early breast cancer in hormone receptor positive postmenopausal women who have received 2 to 3 years of adjuvant tamoxifen. Reduction in the incidence of contralateral breast cancers in post menopausal women receiving Anastrozole as adjuvant treatment for early breast cancer. Treatment of advanced breast cancer in post-menopausal women.
Pharmacology
Anastrozole tablet is a potent and highly selective nonsteroidal aromatase inhibitor. Anastrozole selectively inhibits the conversion of androgens to estrogens, without affecting synthesis of adrenal corticosteroid, aldosterone or thyroid hormone. Suppression of estrogen biosynthesis in all tissues reduces serum concentrations of circulating estrogens, including estrone, estradiol, and estrone sulphate with a subsequent beneficial effect in breast cancer.
Contraindications
Tamoxifen and/or other therapies containing estrogen should not be co-administered with Anastrozole.
Side Effects
Very common side effects: Hot flushes, asthenia, joint stiffness, arthritis, headache, nausea, rash etc. Common side effects: Hair thinning, allergic reactions, diarrhea, vomiting, somnolence etc.
Pregnancy And Lactation
Anastrozole must not be administered during pregnancy or lactation.
Therapeutic
Store in a cool & dry place, protected from light and moisture. Keep out of reach of children.
Over The Counter Products
