Generic
Aripiprazole
Indications
Aripiprazole is indicated for- Schizophrenia Schizoaffective disorder Acute manic and mixed episodes associated with Bipolar I Disorder Maintaining efficacy in patients with Bipolar I Disorder who are stabilized
Pharmacology
Aripiprazole is an atypical antipsychotic that has both dopamine and serotonin receptors activity. It is a partial agonist of dopamine D2 receptors that relieves the symptoms of schizophrenia. It is characterized as a dopamine system stabilizer. It is a potent partial agonist at serotonin 5-HT1A receptors and antagonist at 5-HT2A receptors. This is associated with improvement of depressive, cognitive and negative symptoms.
Dosage Administration
For Schizophrenia: 10 to 15 mg, once daily, without regard to food. Dose increment should not be made before 2 weeks, the time needed to achieve steady state. For Bipolar mania: 30 mg, once daily, without regard to food.
Contraindications
Aripiprazole is contraindicated in patients who are hypersensitive to it or to any component of this product.
Side Effects
Headache, constipation, asthenia, nausea, dyspepsia, vomiting, coughing, abdominal pain.
Pregnancy And Lactation
Aripiprazole should not be used in pregnancy as no human trial is performed. Patients should be advised not to breast feed an infant if they are taking aripiprazole.
Over The Counter Products
