Archi Extra Tablet
Tablet
Aexim Pharmaceuticals Ltd.Generic:
Paracetamol + CaffeineWeight:
500 mg+65 mgbest Price:
৳ 1.50Generic
Paracetamol + Caffeine
Indications
The is indicated in the following condition-
Pharmacology
This is a combination of Paracetamol and Caffeine. Paracetamol has analgesic and antipyretic properties with weak anti-inflammatory activity. Caffeine is an alkaloid which is a theophylline-like xanthine derivative. By intermolecular association with Paracetamol, Caffeine increases the solubility and transmembrane permeation of Paracetamol. In addition, Caffeine increases the pain threshold and tolerance of pain. Caffeine has also an intrinsic power to raise vessel tone in the brain, which provides another benefit to treat migraine and headache.
Dosage Administration
1-2 tablets every 4-6 hours. Maximum dose: 8 tablets daily. : Not recommended for children below 12 years.
Contraindications
May reduce serum levels with anticonvulsants (e.g. phenytoin, barbiturates, carbamazepine). May enhance the anticoagulant effect of warfarin and other coumarins with prolonged use. Accelerated absorption with metoclopramide and domperidone. May increase serum levels with probenecid. May increase serum levels of chloramphenicol. May reduce absorption with colestyramine within 1 hr of admin. May cause severe hypothermia with phenothiazine.
Side Effects
Paracetamol is contraindicated in patients with severe renal function impairment and hepatic disease (Viral Hepatitis). Known hypersensitivity to paracetamol or caffeine.
Pregnancy And Lactation
Side effects of paracetamol are usually mild, though haematological reactions including thrombocytopenia, leukopenia, pancytopenia, neutropenia, and agranulocytosis have been reported. Pancreatitis, skin rashes, and other allergic reactions occur occasionally.
Therapeutic
Non opioid analgesics
Storage Conditions
Store in a cool and dry place, protect from light and moisture.Keep all medicines out of the reach of the children.
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