Arcet Tablet
Tablet
NIPRO JMI Pharma Ltd.Generic:
Cetirizine HydrochlorideWeight:
10 mgbest Price:
৳ 2.01Generic
Cetirizine Hydrochloride
Indications
It is indicated for the relief of symptoms associated with seasonal & perennial allergic rhinitis. It is also indicated for the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria and allergen induced asthma.
Pharmacology
Cetirizine Hydrochloride is a potent H1 receptor antagonist without any significant anticholinergic and antiserotonic effects. At pharmacologically active dose levels, it has almost no drowsiness effect and does not cause behavioral changes. It inhibits the histamine-mediated early phase of the allergic reaction and also reduces the migration of inflammatory cells and the release of mediators associated with the late phase of the allergic reaction.Pharmacokinetics: Cetirizine 10 mg achieves peak plasma concentrations of 257 mcg/L within one hour of administration (980 mcg/L in children). Food does not affect the extent of absorption, but it may slightly reduce the rate. Peak blood levels 0.3 micrograms/ml are reached between thirty & sixty minutes after administration of 10 mg dose of Cetirizine. Its plasma half-life is approximately 11 hours. Absorption is very consistent from one subject to the next. Its renal clearance is 30 ml/minute and the excretion half-life is approximately nine hours.
Dosage Administration
2 tablet or 2 teaspoonfuls daily (or 1 teaspoonful twice daily).: 1 teaspoonful once daily or 1/2 teaspoonful twice daily. : 1/2 teaspoonful once daily. The dose in children 12-23 months of age can be increased to a maximum dose as 1/2 teaspoonful every 12 hours.
Contraindications
No clinically significant drug interactions have been found with Theophylline, Azithromycin, Pseudoephedrine, Ketoconazole or Erythromycin and with other drugs.
Side Effects
It is contraindicated in patients with a history of hypersensitivity to Cetirizine or hydroxyzine.
Pregnancy And Lactation
The most common side effects that occurred more frequently on Cetirizine is somnolence.
Therapeutic
Keep in a dry place away from light and heat. Keep out of the reach of children.
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