Generic
Anastrozole
Pharmacology
Anastrazole exerts its anti-estrogenic effects via selective and competitive inhibition of the aromatase enzyme found predominantly in the adrenal glands, liver, and fatty tissues. Many breast cancers are hormone receptor-positive, meaning their growth is stimulated and/or maintained by the presence of hormones such as estrogen or progesterone. In postmenopausal women, estrogen is primarily derived from the conversion of adrenally-produced androgens into estrogens by the aromatase enzyme- by competitively inhibiting the biosynthesis of estrogen at these enzymes, anastrozole effectively suppresses circulating estrogen levels and, subsequently, the growth of hormone receptor-positive tumours.
Contraindications
Tamoxifen and/or other therapies containing estrogen should not be co-administered with Anastrozole.
Side Effects
Very common side effects: Hot flushes, asthenia, joint stiffness, arthritis, headache, nausea, rash etc. Common side effects: Hair thinning, allergic reactions, diarrhea, vomiting, somnolence etc.
Pregnancy And Lactation
Anastrozole must not be administered during pregnancy or lactation.
Therapeutic
Hormonal Chemotherapy
Storage Conditions
Store in a cool & dry place, protected from light and moisture. Keep out of reach of children.
Over The Counter Products
