Amucef Capsule
Capsule
Amulet Pharmaceuticals Ltd.Generic:
Cefixime TrihydrateWeight:
400 mgbest Price:
৳ 50.00Generic
Cefixime Trihydrate
Indications
Cefixime is indicated in the treatment of the following infections when caused by the susceptible strains of the designated microorganisms: Uncomplicated urinary tract infections caused by Escherichia coli and Proteus mirabilis. Otitis Media caused by Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pyogenes. Pharyngitis and tonsillitis caused by Streptococcus pyogenes. Acute bronchitis and acute exacerbations of chronic bronchitis caused by Streptococcus pneumoniae and Haemophilus influenzae. Uncomplicated gonorrhoea (cervical/urethral) caused by Neisseria gonorrhoeae.
Pharmacology
Cefixime is a third generation semisynthetic cephalosporin antibiotic for oral administration. It is bactericidal against a broad spectrum of gram positive and gram negative bacteria at easily achievable plasma concentrations. It kills bacteria by interfering in the synthesis of bacterial cell wall. It is highly stable in the presence of Beta-lactamase enzyme. As a result, many organisms resistant to penicillins and some cephalsporins due to the presence of beta-lactamases, may be susceptible to Cefixime. Absorption of it is about 40% to 50% whether administered with or without food.
Contraindications
Carbamazepine: Concomitant use elevates the carbamazepine level. Warfarin and other anticoagulants: Concomitant use increases prothrombin time.
Side Effects
It is contraindicated in hypersensitivity to Cefixime or other cephalosporins.
Pregnancy And Lactation
The drug is generally well tolerated. The most frequent side effects are diarrhoea and stool changes; that have been more commonly associated with higher doses. Other side effects are nausea, abdominal pain, dyspepsia, vomiting, flatulence, headache and dizziness. Allergies in the form of rash, pruritus, urticaria, drug fever and arthralgia have been reported. These reactions usually subsided upon dicontinuation of therapy.
Therapeutic
Gastric Lavage may be indicated; otherwise, no specific antidote exists. Cefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis. Adverse reactions in small numbers of healthy adult volunteers receiving single doses up to 2 g of Cefixime did not differ from the profile seen in patients treated at the recommended doses.
Storage Conditions
Third generation Cephalosporins
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