Generic
Allylestrenol
Indications
Allylestrenol is indicated in: Intra Uterine Growth Retardation (IUGR) Threatened abortion Habitual abortion Threatened premature delivery
Pharmacology
Allylestrenol is an oral Gestagen. In castrated animals, it has a potent pregnancy-maintaining action without producing hormonal side-effects, in particular no masculinisation of female foetuses. Clinical studies have indicated that Allylestrenol stimulates the endocrine function of the trophoblast. In vitro, Allylestrenol stimulates the placenta to produce more progesterone. In patients with pregnancy at risk, abnormally low levels of placental hormones (HCG, HPL, oestrogens and progesterone) and some specific enzymes (oxytocinase, CAP) were found to be increased to normal during treatment. In the majority of patients with pregnancy at risk who were treated with Allylestrenol the threat of abortion was removed and pregnancy brought to term without complications. Allylestrenol is very well tolerated. Side-effects of any importance have not been observed.
Contraindications
Breast Cancer or history of problem with the breasts like- Nodules,an abnormal Mammogram, or Fibrocystic Diseases. Severe liver disease such as Cholestatic Jaundice or Hepatitis, Hepatic Cell Tumours, Rotor Syndrome and Dubin Jhonson Syndrome. Undiagnosed vaginal bleeding Toxaemia of Pregnancy Crisis Seizures, Migraines
Side Effects
Treatment with Allylestrenol (especially a long term treatment) is known to cause some gastrointestinal complaints such as vomiting, nausea, and sometimes epigastric discomfort.
Pregnancy And Lactation
Allylestrenol is specifically designed to be taken during pregnancy. It should be discontinued after delivery as it may affect a nursing infant to a small but noticeable degree.
Therapeutic
Female Sex hormones
Storage Conditions
Keep below 30�C temperature, away from light & moisture. Keep out of the reach of children.
Over The Counter Products
