Aggra
SC Injection
Incepta Pharmaceuticals Ltd.Generic:
AdalimumabWeight:
40 mg/0.8 mlbest Price:
৳15000.00Generic
Adalimumab
Indications
Adalimumab is a tumor necrosis factor (TNF) blocker indicated for treatment of: Rheumatoid Arthritis (RA): Reducing signs and symptoms, inducing major clinical response, inhibiting the progression of structural damage, and improving physical function in adult patients with moderately to severely active RA ... Read more
Contraindications
Abatacept: Increased risk of serious infection Anakinra: Increased risk of serious infection Live vaccines: Adalimumab use should be avoided
Side Effects
Adalimumab should not be administered to patients with known hypersensitivity to Adalimumab or any of its components.
Pregnancy And Lactation
The most common adverse reaction with Adalimumab was injection site reactions (erythema and/or itching, hemorrhage, pain or swelling). The most common adverse reactions leading to discontinuation of Adalimumab in rheumatoid arthritis were clinical flare reaction, rash and pneumonia. Other adverse reactions of Adalimumab includes- Gastrointestinal disorders: Diverticulitis, large bowel perforations including perforations associated with diverticulitis and appendiceal perforations associated with appendicitis, pancreatitis. General disorders and administration site conditions: Pyrexia. Hepato-biliary disorders: Liver failure, hepatitis. Immune system disorders: Sarcoidosis. Neoplasms benign, malignant and unspecified (including cysts and polyps): Merkel Cell Carcinoma (neuroendocrine carcinoma of the skin). Nervous system disorders: Demyelinating disorders (e.g., optic neuritis, Guillain-Barr� syndrome). Cerebrovascular accident Respiratory disorders: Interstitial lung disease, including pulmonary fibrosis. Pulmonary embolism Skin reactions: Stevens Johnson Syndrome, cutaneous vasculitis, erythema multiforme, new or worsening psoriasis (all sub-types including pustular and palmoplantar), alopecia. Vascular disorders: Systemic vasculitis, deep vein thrombosis.
Therapeutic
Pediatric Use: Safety and efficacy of Adalimumab in pediatric patients for uses other than polyarticular juvenile idiopathic arthritis (JIA) and pediatric Crohn�s disease have not been established. Geriatric Use: A total of 519 patients 65 years of age and older, including 107 patients 75 years and older, received Adalimumab in clinical studies. No overall difference in effectiveness was observed between these subjects and younger subjects. The frequency of serious infection and malignancy among Adalimumab treated subjects over age 65 was higher than for those under age 65. Because there is a higher incidence of infections and malignancies in the elderly population in general, caution should be used when treating the elderly.
Storage Conditions
The maximum tolerated dose of Adalimumab has not been established in humans. Multiple doses up to 10 mg/kg have been administered to patients in clinical trials without evidence of dose-limiting toxicities. In case of overdosage, it is recommended that the patient be monitored for any signs or symptoms of adverse reactions or effects and appropriate symptomatic treatment instituted immediately.
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