Agedefy Tablet
Dispersible Tablet
Healthcare Pharmaceuticals Ltd.Generic:
Montelukast SodiumWeight:
5 mgbest Price:
৳ 8.00Generic
Montelukast Sodium
Pharmacology
Montelukast is a selective and orally active leukotriene receptor antagonist that inhibits the cysteinyl leukotriene receptor (CysLT1). The cysteinyl leukotrienes (LTC4, LTD4, LTE4) are products of arachidonic acid metabolism and are released from various cells, including mast cells and eosinophils. Cysteinyl leukotrienes and leukotriene receptor occupation have been correlated with the pathophysiology of asthma & allergic rhinitis, including airway edema, smooth muscle contraction, and altered cellular activity associated with the inflammatory process, which contribute to the signs and symptoms of asthma.
Dosage Administration
Adults & adolescents (15 years & older)- Asthma & Allergic Rhinitis: 10 mg/day Exercise-Induced Bronchoconstriction: 10 mg/day Pediatric patients (6 to 14 years)- Asthma & Allergic Rhinitis: 5 mg/day Exercise-Induced Bronchoconstriction: 5 mg/day Pediatric patients (6 months to 5 years)- Asthma & Allergic Rhinitis: 4 mg/day Exercise-Induced Bronchoconstriction: Not recommended Patients with both asthma and allergic rhinitis should take only one dose daily in the evening. For prevention of Acute prevention of Exercise-Induced Bronchoconstriction, a single dose should be taken at least 2 hours before exercise.
Side Effects
With medicine: No dose adjustment is needed when montelukast is co-administered with theophylline, prednisone, prednisolone, terfenadine, digoxin, warfarin, gemfibrozil, itraconazole, thyroid hormones, sedative-hypnotics, non-steroidal anti-inflammatory agents, benzodiazepines, decongestants, oral contraceptives, and Cytochrome P450 (CYP) enzyme inducers. With food and others: Bioavailability and other conditions were not significantly observed with food & other conditions.
Pregnancy And Lactation
Montelukast is contraindicated in patients who are hypersensitive to any component of this product.
Therapeutic
Montelukast is not indicated for use in the reversal of bronchospasm in acute asthma attacks, including status asthmatic. Neuropsychiatric events including agitation, hostility, anxiousness, depression, disorientation, disturbance in attention, dream abnormalities, hallucinations, insomnia, irritability, memory impairment, restlessness, somnambulism, suicidal thinking and behavior (including suicide) and tremor.
Storage Conditions
There were no adverse experiences in the majority of overdosage reports. The most frequently occurring adverse experiences were consistent with the safety profile of Montelukast and included abdominal pain, somnolence, thirst, headache, vomiting and psychomotor hyperactivity. In the event of overdose, it is reasonable to employ the usual supportive measures; e.g., remove unabsorbed material from the gastrointestinal tract, employ clinical monitoring, and institute supportive therapy, if required.
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