Adlinameg Tablet
IV Infusion
Aristopharma Ltd.Generic:
AcyclovirWeight:
250 mg/vialbest Price:
৳ 400.00Generic
Acyclovir
Indications
Acyclovir intravenous infusion is indicated for the treatment of- Acute clinical manifestations of Herpes simplex virus in immunocompromised patients Severe primary or non-primary genital herpes in immune competent patients Varicella zoster virus infection in immunocompromised patients ... Read moreAcyclovir intravenous infusion is indicated for the treatment of- Acute clinical manifestations of Herpes simplex virus in immunocompromised patients Severe primary or non-primary genital herpes in immune competent patients Varicella zoster virus infection in immunocompromised patients Herpes zoster (shingles) in immune competent patients who show very severe acute local or systemic manifestations of the disease Herpes simplex encephalitis
Contraindications
Acyclovir IV Injection is contraindicated in patients known to be hypersensitive to Acyclovir or Valacyclovir.
Side Effects
Some infrequent adverse reactions are lethargy, obtundation, tremors, confusion, hallucinations, agitation, somnolence, psychosis, convulsions and coma, phlebitis, nausea, vomiting, reversible increases in liver-related enzymes, pruritus, urticaria, rashes, increases in blood urea and creatinine. Local inflammatory reactions may occur if Acyclovir IV Infusion is inadvertently infused into extracellular tissues.
Pregnancy And Lactation
Acyclovir IV injection is intended for intravenous infusion only and should not be used through any other route. Reconstituted Acyclovir IV Infusion has a pH of approximately 11.0 and should not be administered by mouth. Acyclovir IV injection as infusion must be given over a period of at least one hour in order to avoid renal tubular damage. It should not be administered as a bolus injection. Acyclovir IV infusion must be accompanied by adequate hydration. Since maximum urine concentration occurs within the first few hours following infusion, particular attention should be given to establish sufficient urine ‑ow during that period. Concomitant use of other nephrotoxic drugs, pre-existing renal disease and dehydration increase the risk of further renal impairment by Acyclovir. As Acyclovir has been associated with reversible encephalopathic changes, it should be used with caution in patients with neurological abnormalities, significant hypoxia or serious renal, hepatic or electrolyte abnormalities.
Therapeutic
Pediatric use: The dose of Acyclovir IV injection in children aged 1-12 years should be calculated on the basis of body surface area. Children in this age group with Herpes simplex infections (except Herpes simplex encephalitis) or Varicella zoster infections should be given Acyclovir IV Infusion in doses of 250 mg/m2 (equivalent to 5 mg/kg in adults). Immunocompromised children in this age group with Varicella zoster virus infection or with Herpes simplex encephalitis should be given Acyclovir IV Infusion in doses of 500 mg/m2 (equivalent to 10 mg/kg in adults). Children with impaired renal function require an appropriately modified dose, according to the degree of impairment. Geriatric use: No data are available on this age group. However, as creatinine clearance is often low in the elderly, special attention should be given to dosage reduction. In patients with renal impairment: Acyclovir should be administered with caution since the drug is excreted through the kidneys. The following modifications in dosage are suggested: CrCl: 25-50 ml/min: 5 or 10 mg/kg every 12 hours CrCl: 10-25 ml/min: 5 or 10 mg/kg every 24 hours CrCl: 0-10 ml/min: 2.5 or 5 mg/kg every 24 hours and after dialysis.
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