Acme's ORS Oral Powder
Capsule
ACI LimitedGeneric:
Cefaclor MonohydrateWeight:
250 mgbest Price:
৳ 21.14Generic
Cefaclor Monohydrate
Pharmacology
Adult- Usual dose: 250 mg 8 hrly. Bronchitis & pneumonia: 250 mg tid. Sinusitis: 500 mg tid for 10 days. Pneumonia & other more severe infections: Max: 4 gm/day for 28 days. Acute gonococcal urethritis: 3 gm as a single dose combined with probenecid 1 gm. Children- Recommended dose: 20 mg/kg/day in divided doses 8 hrly. Bronchitis & pneumonia: 20 mg/kg/day in divided doses tid. Serious infections, sinusitis, otitis media & infections: caused by less susceptible organisms 40 mg/kg/day in divided doses. Max: 1 gm/day.
Dosage Administration
Adult- Usual dose: 250 mg 8 hrly. Bronchitis & pneumonia: 250 mg tid. Sinusitis: 500 mg tid for 10 days. Pneumonia & other more severe infections: Max: 4 gm/day for 28 days. Acute gonococcal urethritis: 3 gm as a single dose combined with probenecid 1 gm. Children- Recommended dose: 20 mg/kg/day in divided doses 8 hrly. Bronchitis & pneumonia: 20 mg/kg/day in divided doses tid. Serious infections, sinusitis, otitis media & infections: caused by less susceptible organisms 40 mg/kg/day in divided doses. Max: 1 gm/day.
Side Effects
The nephrotoxicity of aminoglycoside antibiotics such as gentamicin and tobramicin may be enhanced by any cephalosporin. Therefore, one should be cautious in concomitant use of these categories of drugs.
Pregnancy And Lactation
Cefaclor is contraindicated in patients with known allergy to the Cephalosporin group of antibiotics.
Therapeutic
Gastro-intestinal: Diarrhoea, nausea and vomiting have been reported. Hypersensitivity: Allergic reactions such as eruptions, pruritis and urticaria have been observed. These reactions usually subside upon discontinuation of therapy. Serum sickness like reactions have been reported. Haematological: Eosinophilia, thrombocytopenia, transient lymphocytosis and leucopenia may occur rarely. Hepatic: Transient hepatitis and cholestatic jaundice, slight elevation in AST, ALT or alkaline phosphate values have been reported rarely. Renal: Reversible interstitial nephritis has occurred rarely, also slight elevations in blood urea or serum creatinine or abnormal urinalysis. Central Nervous System: Reversible hyperactivity, nervousness, confusion, hypertonia, dizziness, hallucinations and somnolence have been reported rarely.
Storage Conditions
There are no adequate and well-controlled studies in pregnant women. This drug should be used during pregnancy only if clearly needed. Small amounts of Cefaclor have been detected in mother's milk. The effect on nursing infants is not known. Caution should be exercised when Cefaclor is administered to a nursing woman.
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